The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling
has contributed to a new classification of lung cancer, driving advancements in research and …

LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung
cancer (NSCLC) and cause aggressive tumor growth. Unfortunately, treatment with RAS …

KRAS, one of the RAS protein family members, plays an important role in autophagy and
apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS …

KRAS mutations are one of the most frequent oncogenic mutations of all human cancers,
being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been …

Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

Autophagy is a conserved catabolic process that maintains cellular homeostasis. Autophagy
supports lung tumorigenesis and is a potential therapeutic target in lung cancer. A better …

Background Brain metastases present a significant complication in lung cancer with an
unmet therapeutic need. Methods In this single-centre, retrospective study, we genotyped a …

Macroautophagy is a health-modifying process of engulfing misfolded or aggregated
proteins or damaged organelles, coating these proteins or organelles into vesicles, fusion of …

Advancements in the development of computer-aided decision (CAD) systems for clinical
routines provide unquestionable benefits in connecting human medical expertise with …