Ischemic stroke is one of the leading causes of mortality and disability worldwide. However,
there is a current lack of effective therapies available. As the resident macrophages of the …

Gene transfer has long been a compelling yet elusive therapeutic modality. First mainly
considered for rare inherited disorders, gene therapy may open treatment opportunities for …

Impaired activation and regulation of the extinction of inflammatory cells and molecules in
injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly …

Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia
and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype …

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …

CD4+ T cells differentiated into Th17 cells are a main cause for occurrence and
development of rheumatoid arthritis (RA). This study aims to define the role of long …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

It is crucial to understand the molecular mechanisms involved in epileptogenesis. This study
aims to investigate the role of lncRNA NEAT1, miR-129-5p and Notch signaling pathway in …

Long non-coding RNAs (lncRNAs) were considered as accumulated genetic waste until they
were found to be gene expression regulators by highly sensitive modern genomics …