Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell
differentiation, and cell metabolism in many different cell types, both during embryogenesis …

Organogenesis requires the orchestrated development of multiple cell lineages that
converge, interact, and specialize to generate coherent functional structures, exemplified by …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …

The endoderm is the cell lineage which gives rise in the embryo to the organs of the
respiratory and gastrointestinal system. In the mouse this may be the germ layer with the …

The gastrointestinal (GI) tract is complex and consists of multiple organs with unique
functions. Rare gene variants can cause congenital malformations of the human GI tract …

Adriamycin (ADR), one of the most effective broad-spectrum antitumor chemotherapeutic
agents in clinical practice, is used to treat solid tumors as well as hematological …

Many developmental signaling pathways have been implicated in lineage-specific
differentiation; however, mechanisms that explicitly control differentiation timing remain …

Cardiopulmonary progenitor cells (CPPs) constitute a minor subpopulation of cells that are
commonly associated with heart and lung morphogenesis during embryonic development …

Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte
(AC) differentiation. However, little is known about the mechanisms directing Nr2f …