A review: inflammatory process in Alzheimer′ s disease, role of cytokines
JM Rubio-Perez… - The Scientific World …, 2012 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disorder to date.
Neuropathological hallmarks are β‐amyloid (Aβ) plaques and neurofibrillary tangles, but the …
Neuropathological hallmarks are β‐amyloid (Aβ) plaques and neurofibrillary tangles, but the …
Rho signaling in synaptic plasticity, memory, and brain disorders
Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …
disease, and depression. Forming memories involves modifications of synaptic transmission …
Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK …
YF Liao, BJ Wang, HT Cheng, LH Kuo… - Journal of Biological …, 2004 - ASBMB
The deposition of the amyloid β (Aβ) peptide in neuritic plaques plays a critical role in the
pathogenesis of Alzheimer's disease (AD). Aβ is generated through the proteolysis of …
pathogenesis of Alzheimer's disease (AD). Aβ is generated through the proteolysis of …
Distinct cytokine profiles in human brains resilient to Alzheimer's pathology
Our group has previously studied the brains of some unique individuals who are able to
tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and …
tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and …
Synaptic NMDA receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production
SE Hoey, RJ Williams, MS Perkinton - Journal of Neuroscience, 2009 - Soc Neuroscience
Altered amyloid precursor protein (APP) processing leading to increased production and
oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP …
oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP …
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment
Altered levels of cerebrospinal fluid (CSF) peptides related to Alzheimer's disease (AD) are
associated with pathologic AD diagnosis, although cognitively normal subjects can also …
associated with pathologic AD diagnosis, although cognitively normal subjects can also …
PDGF/PDGFR axis in the neural systems
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in
several cell types including the brain cells such as neuronal progenitors, neurons …
several cell types including the brain cells such as neuronal progenitors, neurons …
Gleevec inhibits β-amyloid production but not Notch cleavage
Amyloid-β (Aβ) peptides, consisting mainly of 40 and 42 aa (Aβ40 and Aβ42, respectively),
are metabolites of the amyloid precursor protein and are believed to be major pathological …
are metabolites of the amyloid precursor protein and are believed to be major pathological …
β‐but not γ‐secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
R Tamayev, S Matsuda, O Arancio… - EMBO molecular …, 2012 - embopress.org
A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish
dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid‐β precursor …
dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid‐β precursor …
APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells
G De Chiara, ME Marcocci, L Civitelli, R Argnani… - PloS one, 2010 - journals.plos.org
Lifelong latent infections of the trigeminal ganglion by the neurotropic herpes simplex virus
type 1 (HSV-1) are characterized by periodic reactivation. During these episodes, newly …
type 1 (HSV-1) are characterized by periodic reactivation. During these episodes, newly …