The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon
monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Acute kidney injury (AKI) represents a common complication in critically ill patients that is
associated with increased morbidity and mortality. In a murine AKI model induced by …

Ferroptosis, a novel form of regulated cell death, is characterized by imbalance of
intracellular iron and redox systems, resulting from overgeneration of toxic lipid peroxidation …

Background The reactive oxygen species (ROS) and inflammation, a critical contributor to
tissue damage, is well-known to be associated with various disease. The kidney is …