[HTML][HTML] SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines

S Pather, SA Madhi, BJ Cowling, P Moss… - Frontiers in …, 2023 - frontiersin.org
The highly transmissible Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …

Immune imprinting and next-generation coronavirus vaccines

CQ Huang, S Vishwanath, GW Carnell, ACY Chan… - Nature …, 2023 - nature.com
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

[HTML][HTML] Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants

P Qu, K Xu, JN Faraone, N Goodarzi, YM Zheng… - Cell, 2024 - cell.com
Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we
characterized BA. 2.86 and XBB-derived variant FLip by investigating their neutralization …

Immune evasion and membrane fusion of SARS-CoV-2 XBB subvariants EG. 5.1 and XBB. 2.3

JN Faraone, P Qu, N Goodarzi, YM Zheng… - Emerging Microbes & …, 2023 - Taylor & Francis
Immune evasion by SARS-CoV-2 paired with immune imprinting from monovalent mRNA
vaccines has resulted in attenuated neutralizing antibody responses against Omicron …

Less neutralization evasion of SARS-CoV-2 BA. 2.86 than XBB sublineages and CH. 1.1

Y Hu, J Zou, C Kurhade, X Deng… - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB. 1.5 and BQ. 1.1 subvariants

D Ao, X He, W Hong, X Wei - MedComm, 2023 - Wiley Online Library
As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B. 1.1. 529)
has quickly become the dominant type among the previous circulating variants worldwide …

[HTML][HTML] Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

K McMahan, F Wegmann, M Aid, M Sciacca, J Liu… - Nature, 2024 - nature.com
A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against
infection with current Omicron subvariants,, although they still provide protection against …

[HTML][HTML] Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB. 1.5

M Hoffmann, P Arora, I Nehlmeier, A Kempf… - Cellular & Molecular …, 2023 - nature.com
Since late 2022, the share of infections caused by the SARS-CoV-2 lineage XBB. 1.5 has
gradually increased in the United States, resulting in XBB. 1.5 becoming the dominating …

[HTML][HTML] Effectiveness of BNT162b2 BA. 4/5 bivalent mRNA vaccine against a range of COVID-19 outcomes in a large health system in the USA: A test-negative case …

SY Tartof, JM Slezak, L Puzniak, V Hong… - The Lancet …, 2023 - thelancet.com
Background XBB-related omicron sublineages have recently replaced BA. 4/5 as the
predominant omicron sublineages in the USA and other regions globally. Despite …

Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron

L Wang, M Møhlenberg, P Wang, H Zhou - Cytokine & growth factor …, 2023 - Elsevier
Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …