Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

This article recapitulates the evidence on the role of mammalian targets of rapamycin
(mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect …

Aging is a risk factor for major central nervous system (CNS) disorders. More specifically,
aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact …

Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and
phagocytosis, communicating with neighboring cells and contributing to the integrity of the …

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

Disorders of metabolism affect multiple systems throughout the body but may have the
greatest impact on both central and peripheral nervous systems. Currently available …

Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

Multiple sclerosis (MS) is a chronic disorder characterized by reactive gliosis, inflammation,
and demyelination. Microglia plays a crucial role in the pathogenesis of MS and has the …

Neuronal disorders are associated with a profound loss of mitochondrial functions caused
by various stress conditions, such as oxidative and metabolic stress, protein folding or import …

Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …