Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
Metabolism of tissue macrophages in homeostasis and pathology
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …
anabolism to generate cellular energy and structural components. The emerging field of …
Function of macrophages in disease: current understanding on molecular mechanisms
Tissue-resident macrophages (TRMs) are heterogeneous populations originating either
from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid …
from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid …
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
DW McKellar, LD Walter, LT Song, M Mantri… - Communications …, 2021 - nature.com
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
The many roles of macrophages in skeletal muscle injury and repair
X Wang, L Zhou - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Skeletal muscle is essential to physical activity and energy metabolism. Maintaining intact
functions of skeletal muscle is crucial to health and wellbeing. Evolutionarily, skeletal muscle …
functions of skeletal muscle is crucial to health and wellbeing. Evolutionarily, skeletal muscle …
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations
LK Krasniewski, P Chakraborty, CY Cui… - Elife, 2022 - elifesciences.org
Tissue-resident macrophages represent a group of highly responsive innate immune cells
that acquire diverse functions by polarizing toward distinct subpopulations. The …
that acquire diverse functions by polarizing toward distinct subpopulations. The …
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics
F Babaeijandaghi, R Cheng, N Kajabadi… - Science Translational …, 2022 - science.org
The role of tissue-resident macrophages during tissue regeneration or fibrosis is not well
understood, mainly due to the lack of a specific marker for their identification. Here, we …
understood, mainly due to the lack of a specific marker for their identification. Here, we …
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an
underlying chronic disease, is a key determinant to quality of life and mortality. However …
underlying chronic disease, is a key determinant to quality of life and mortality. However …
A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system
The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system
(MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by …
(MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by …