Next-generation sequencing technology has facilitated the discovery of millions of genetic
variants in human genomes. A sizeable fraction of these variants are predicted to be …

Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …

The unprecedented rate of extinction calls for efficient use of genetics to help conserve
biodiversity. Several recent genomic and simulation-based studies have argued that the …

About 50 y ago, Crow and Kimura [An Introduction to Population Genetics Theory (1970)]
and Ohta and Kimura [Genet. Res. 22, 201–204 (1973)] laid the foundations of conservation …

Despite the substantial role that chickens have played in human societies across the world,
both the geographic and temporal origins of their domestication remain controversial. To …

Measures of selective constraint on genes have been used for many applications, including
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …

Increasing habitat fragmentation leads to wild populations becoming small, isolated, and
threatened by inbreeding depression. However, small populations may be able to purge …

Abstract Approximately 2–4% of genetic material in human populations outside Africa is
derived from Neanderthals who interbred with anatomically modern humans. Recent studies …

Human activity has caused dramatic population declines in many wild species. The resulting
bottlenecks have a profound impact on the genetic makeup of a species with unknown …

Human-driven habitat fragmentation and loss have led to a proliferation of small and
isolated plant and animal populations with high risk of extinction. One of the main threats to …