In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

Breast cancer (BC) has yielded approximately 2.26 million new cases and has caused
nearly 685,000 deaths worldwide in the last two years, making it the most common …

Triple-negative breast cancer (TNBC) is an aggressive disease that disproportionately
affects African American (AA) women. Limited targeted therapeutic options exist for patients …

Although intratumoral genomic heterogeneity can impede cancer research and treatment,
less is known about the effects of phenotypic heterogeneities. To investigate the role of cell …

The metastatic process is arduous. Cancer cells must escape the confines of the primary
tumor, make their way into and travel through the circulation, then survive and proliferate in …

Currently, a new line of research on mitochondria-targeted anticancer drugs is actively
developing in the field of biomedicine and medicinal chemistry. The distinguishing features …

Background: Cancer metastasis is a deathly process, and a better understanding of the
different steps is needed. The shedding of circulating tumor cells (CTCs) and CTC-cluster …

The tumor microenvironment is increasingly recognized as key player in cancer progression.
Investigating heterotypic interactions between cancer cells and their microenvironment is …

It is traditionally assumed that during cancer development, tumor cells abort their initially
cooperative behavior (ie, cheat) in favor of evolutionary strategies designed solely to …

The major underlying cause for the high mortality rate in colorectal cancer (CRC) relies on
its drug resistance, to which intratumor heterogeneity (ITH) contributes substantially. CRC …