[HTML][HTML] Gates of enzymes

A Gora, J Brezovsky, J Damborsky - Chemical reviews, 2013 - ACS Publications
Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

Channeling of substrates and intermediates in enzyme-catalyzed reactions

X Huang, HM Holden… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The three-dimensional structures of tryptophan synthase, carbamoyl phosphate
synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, and asparagine …

[PDF][PDF] Autoimmune hepatitis, from mechanisms to therapy

MP Manns, A Vogel - Hepatology, 2006 - Wiley Online Library
In 1950, Waldenström was the first to describe a chronic form of hepatitis in young women.
Subsequently, the disease was found to be associated with other autoimmune syndromes …

The use of enzymes in organic synthesis and the life sciences: perspectives from the Swiss Industrial Biocatalysis Consortium (SIBC)

HP Meyer, E Eichhorn, S Hanlon, S Lütz… - Catalysis Science & …, 2013 - pubs.rsc.org
The potential of biotechnology by means of biocatalysis or biosynthesis in organic synthesis
is far from being fully exploited. For this reason a group of life science companies active in …

The folate cycle and disease in humans

B Fowler - Kidney International, 2001 - kidney-international.org
The folate cycle and disease in humans. The prevalence of hyperhomocysteinemia in renal
disease patients, its treatment by folate administration, and its aggravation by the 677 C→ T …

Structure and Mechanism of Peptide Methionine Sulfoxide Reductase, an “Anti-Oxidation” Enzyme,

WT Lowther, N Brot, H Weissbach, BW Matthews - Biochemistry, 2000 - ACS Publications
Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free
methionine and methionine within proteins. As such, it helps protect the host organism …

Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis

SX Li, YP Tong, XC Xie, QH Wang, HN Zhou… - Journal of molecular …, 2007 - Elsevier
Phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole
succinocarboxamide synthetase (PAICS) is an important bifunctional enzyme in de novo …

[HTML][HTML] Channelling and formation of 'active'formaldehyde in dimethylglycine oxidase

D Leys, J Basran, NS Scrutton - The EMBO journal, 2003 - embopress.org
Here we report crystal structures of dimethylglycine oxidase (DMGO) from the bacterium
Arthrobacter globiformis, a bifunctional enzyme that catalyzes the oxidation of N, N‐dimethyl …

Evolution of a Saccharomyces cerevisiae metabolic pathway in Escherichia coli

IM Salles, N Forchhammer, C Croux, L Girbal… - Metabolic …, 2007 - Elsevier
The Saccharomyces cerevisiae glycerol pathway (GPD1 and GPP2) was evolved in vivo in
Escherichia coli. The central metabolism of E. coli was engineered to link glucose …

[图书][B] Springer Handbook of Enzymes: Class 2• Transferases X EC 2.7. 1.113–2.7. 5.7

D Schomburg, I Scomburg, A Chang - 2007 - Springer
Nomenclature EC number 2.7. 2.3 Systematic name ATP: 3-phospho-D-glycerate 1-
phosphotransferase Recommended name phosphoglycerate kinase Synonyms 3-PGK 3 …