Investigating the neuronal dynamics supporting brain functions and understanding how the
alterations in these mechanisms result in pathological conditions represents a fundamental …

Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons and
accumulation of misfolded alpha-synuclein (αSyn) into Lewy bodies. In addition to motor …

The major neuropathologic feature of Parkinson's disease is the presence of widespread
intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these …

Cognitive dysfunction is a salient feature of Parkinson's disease (PD) and Dementia with
Lewy bodies (DLB). The onset of dementia reflects the spread of Lewy pathology throughout …

Pre-formed fibrils (PFFs) made from recombinant α-synuclein are broadly used throughout
the field in cellular and animal models of Parkinson's disease. However, their ability to …

Dysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in
Parkinson disease (PD). While cortical function is known to be suppressed by abnormal …

The segregation of processes into cortical layers is a convergent feature in animal evolution.
However, how changes in the cortical layer architecture affect sensory system function and …

Parkinson's disease (PD) is the fastest growing neurodegenerative disease, and in an
increasingly aged population the care and management of PD is an increasing global …

Parkinsons disease (PD) is a progressive neurodegenerative disorder characterized by the
abnormal accumulation of α-synuclein in the brain that triggers a series of neuropathological …