Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own
reading frames by generating double strand breaks at specific genomic invasion sites …

It has been theorized that inducing extreme reproductive sex ratios could be a method to
suppress or eliminate pest populations. Limited knowledge about the genetic makeup and …

DNA and a large proportion of RNA are antiparallel duplexes composed of an unvarying
phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How …

The families of the plant-specific transcription factors (TFs) are defined by their characteristic
DNA-binding domains (DBDs), such as AP2/ERF, B3, NAC, SBP, and WRKY. Recently …

Homing endonucleases confer mobility to their host intervening sequence, either an intron
or intein, by catalyzing a highly specific double-strand break in a cognate allele lacking the …

Many craniofacial disorders are caused by heterozygous mutations in general regulators of
housekeeping cellular functions such as transcription or ribosome biogenesis,. Although it is …

We developed a novel system to create DNA double-strand breaks (DSBs) at defined
endogenous sites in the human genome, and used this system to detect protein recruitment …

There is a growing interest in structural studies of DNA by both experimental and
computational approaches. Often, 3D-structural models of DNA are required, for instance, to …

Meganucleases are sequence-specific endonucleases recognizing large (> 12 bp)
sequence sites and several laboratories have used these proteins to induce highly efficient …