Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …

Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are
activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a …

Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates
diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the …

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but
chemokine network redundancy thwarts pharmacological intervention. Tick evasins …

Chemokines (chemotactic cytokines) and their receptors are critical to recruitment and
positioning of cells during development and the immune response. The chemokine system …

The pleiotropic chemokine CXCL12 is involved in diverse physiological and
pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte …

CXCR4 binding of its endogenous agonist CXCL12 leads to diverse functions, including
bone marrow retention of hematopoietic progenitors and cancer metastasis. However, the …

The concept of ligand–receptor binding kinetics has been broadly applied in drug
development pipelines focusing on G protein-coupled receptors (GPCRs). The ligand …

Because of their prominent roles in development, cancer, and HIV, the chemokine receptor
CXCR4 and its ligand CXCL12 have been the subject of numerous structural and functional …