Abstract According to the 2008 World Health Organization classification system for
hematologic malignancies, the myeloproliferative neoplasms (MPN) include chronic …

Myelofibrosis with myeloid metaplasia (MMM) is a clinicopathologic entity characterized by
stem cell-derived clonal myeloproliferation, ineffective erythropoiesis, extramedullary …

The classic Philadelphia chromosome–negative myeloproliferative neoplasms (MPN)
consist of myelofibrosis, polycythemia vera, and essential thrombocythemia and are a …

Background The JAK2V617F allele has recently been identified in patients with
polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid …

Bayesian Designs for Phase I–II Clinical Trials Page 1 Page 2 Ying Yuan The University of
Texas MD Anderson Cancer Center Houston, Texas, USA Hoang Q. Nguyen The University of …

Perhaps no other drug in modern medicine rivals the dramatic revitalization of thalidomide.
Originally marketed as a sedative, thalidomide gained immense popularity worldwide …

We present results of 2 similarly designed but separate phase 2 studies involving single-
agent lenalidomide (CC-5013, Revlimid) in a total of 68 patients with symptomatic …

Purpose To investigate the safety and efficacy of the combination of lenalidomide and
prednisone in patients with myelofibrosis (MF). Patients and Methods Forty patients with MF …

It is currently assumed that myelofibrosis (MF) originates from acquired mutations that target
the hematopoietic stem cell and induce dysregulation of kinase signaling, clonal …

A total of 21 patients with myelofibrosis with myeloid metaplasia (MMM), with a median age
of 54 years (range, 27-68 years), were prepared with a reduced-intensity conditioning (RIC) …