At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers
the antitumor immune response. Here, we report a denaturation-and-penetration strategy …

Atherosclerosis (AS) is a major cause of cardiovascular diseases such as coronary heart
disease, heart failure and stroke. Abnormal lipid metabolism, oxidative stress and …

Atherosclerosis is a chronic, multifactorial disease that starts in youth, manifests clinically
later in life, and can lead to myocardial infarction, stroke, claudication, and death. Although …

Abstract Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone
which mediates many cellular processes such as cell transformation, proliferation, and …

To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting
at 20 months, would lead to different survival outcomes, we compared three dosing …

Heat shock proteins (HSPs) of eukaryotes are evolutionarily conserved molecules present in
all the major intracellular organelles. They mainly function as molecular chaperones and …

Heat shock protein (HSP) 90 is the most abundant HSPs, which are chaperone molecules
whose major roles are cell protection and maintenance by means of aiding the folding, the …

Cardiovascular disease is the result of complicated pathophysiological processes in the
tissues that make up the blood vessels and heart. Heat shock protein 90 (HSP90) can …