Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface
of jawless fishes. Over the course of 500,000,000 years of evolution, many of those …

Wnt/β-catenin signaling plays key roles in tooth development, but how this pathway
intersects with the complex interplay of signaling factors regulating dental morphogenesis …

This paper reviews the concept of morphogenetic fields within the dentition that was first
proposed by Butler (Butler PM. Studies of the mammalian dentition. Differentiation of the …

Teeth are unique to vertebrates and have played a central role in their evolution. The
molecular pathways and morphogenetic processes involved in tooth development have …

Teeth organogenesis develops through a well-ordered series of inductive events involving
genes and BMP, FGF, SHH and WNT represent the main signalling pathways that regulate …

Substantial advancements have been made in defining the cells and molecular signals that
guide tooth crown morphogenesis and development. As a result, very encouraging progress …

Non-syndromic tooth agenesis (NSTA) is one of the most common dental developmental
malformations affected by genetic factors predominantly. Among all 36 candidate genes …

TRAF6 is divergent from other members of the TRAF family. Therefore, TRAF6 was expected
to play physiological roles distinct from those of other TRAFs. In this chapter, we focused on …

The hypohidrotic ectodermal dysplasias (HED) belong to a large and heterogenous
nosological group of polymalfomative syndromes characterized by dystrophy or agenesis of …