GB virus C: the good boy virus?

N Bhattarai, JT Stapleton - Trends in microbiology, 2012 - cell.com
GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to
hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any …

Human pegivirus type 1 infection in Asia—A review of the literature

J Zimmerman, JT Blackard - Reviews in medical virology, 2022 - Wiley Online Library
The human pegivirus type 1 (HPgV‐1)—as known as hepatitis G virus and GB virus C—is a
common single‐stranded RNA flavivirus. Because few studies have demonstrated an …

GB virus type C infection modulates T-cell activation independently of HIV-1 viral load

MT Maidana-Giret, TM Silva, MM Sauer, H Tomiyama… - Aids, 2009 - journals.lww.com
Background: Many clinical studies have suggested a beneficial effect of GB virus type C
(GBV-C) on the course of HIV-1 infection, but the mechanisms involved in such amelioration …

Acquisition of GB virus type C and lower mortality in patients with advanced HIV disease

F Vahidnia, M Petersen, JT Stapleton… - Clinical infectious …, 2012 - academic.oup.com
Background. GB virus type C (GBV-C) is transmitted by sexual or parenteral exposure and is
prevalent among patients receiving blood products. GBV-C is associated with lower human …

Role of GB virus C in modulating HIV disease

C Schwarze-Zander, JT Blackard… - Expert review of anti …, 2012 - Taylor & Francis
GB virus C (GBV-C) is a member of the Flaviviridae family and the most closely related
human virus to HCV. However, GBV-C does not replicate in hepatocytes, but rather in …

GB virus C infection is associated with a reduced rate of reactivation of latent HIV and protection against activation-induced T-cell death

RT Rydze, N Bhattarai, JT Stapleton - Antiviral therapy, 2012 - journals.sagepub.com
Background GB virus C (GBV-C) coinfection is associated with reduced immune activation
and a block in CD4+ T-cell proliferation following interleukin-2 (IL-2) therapy in HIV-infected …

Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor

MJ Gómara, V Sánchez-Merino, A Paús… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background: A slower progression of AIDS and increased survival in GBV-C positive
individuals, compared with GBV-C negative individuals has been demonstrated; while the …

GB virus C: insights into co-infection

MD Berzsenyi, DS Bowden, SK Roberts - Journal of Clinical Virology, 2005 - Elsevier
GB virus C (GBV-C) is a single stranded positive sense RNA virus, which is a member of the
Flaviviridae. It has a close sequence homology and genomic organisation to hepatitis C …

Impact of GB virus C viraemia on clinical outcome in HIV‐1‐infected patients: a 20‐year follow‐up study

D Ernst, M Greer, R Akmatova, S Pischke… - HIV …, 2014 - Wiley Online Library
Objectives The impact of coexisting GB virus C (GBV‐C) infection on the clinical course of
HIV infection remains controversial. Early data from HIV‐1 infected patients attending the …

The impact of human pegivirus on CD4 cell count in HIV-positive persons in Botswana

KF N'Guessan, M Anderson, B Phinius… - Open forum …, 2017 - academic.oup.com
Abstract Background Human pegiviruses (HPgV)—formerly known as hepatitis G virus or GB
virus C (GBV-C)—are common single-stranded RNA viruses that may have a beneficial …