Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene,
underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its …

ATP-dependent chromatin remodeling is an essential process required for the dynamic
organization of chromatin structure. Here we describe the genome-wide location and activity …

Background Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Skin
barrier defects contribute to disease initiation and development; however, underlying …

Skeletal muscle regeneration is mediated by myoblasts that undergo epigenomic changes
to establish the gene expression program of differentiated myofibers. mSWI/SNF chromatin …

The N-acetyltransferase arrest defective 1 (ARD1) is an important regulator of cell growth
and differentiation that has emerged recently as a critical molecule in cancer progression …

The progression to advanced stage cancer requires changes in many characteristics of a
cell. These changes are usually initiated through spontaneous mutation. As a result of these …

MicroRNAs have emerged as critical regulators in the pathogenesis of asthma. However, the
role of microRNAs in asthma needs to be further elucidated. In this study, we found that miR …

Abstract Background CDKN2A/p16 INK4a is frequently altered in human cancers and it is
the most important melanoma susceptibility gene identified to date. p16 INK4a inhibits pRb …