[HTML][HTML] GM-CSF in inflammation

JA Hamilton - Journal of Experimental Medicine, 2020 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

[HTML][HTML] IgA and FcαRI: pathological roles and therapeutic opportunities

A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

Tumor-associated neutrophils: friend or foe?

ZG Fridlender, SM Albelda - Carcinogenesis, 2012 - academic.oup.com
Neutrophils play an established role in host defense and in killing invading microorganisms.
Although neutrophils are traditionally considered in the context of their antibacterial …

Biomaterials for vaccine-based cancer immunotherapy

R Zhang, MM Billingsley, MJ Mitchell - Journal of Controlled Release, 2018 - Elsevier
The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …

Injectable, porous, and cell-responsive gelatin cryogels

ST Koshy, TC Ferrante, SA Lewin, DJ Mooney - Biomaterials, 2014 - Elsevier
The performance of biomaterials-based therapies can be hindered by complications
associated with surgical implant, motivating the development of materials systems that allow …

Neutrophils in traumatic brain injury (TBI): friend or foe?

YW Liu, S Li, SS Dai - Journal of neuroinflammation, 2018 - Springer
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited.
Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated …

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

JA Hamilton, AD Cook, PP Tak - Nature reviews Drug discovery, 2017 - nature.com
Granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-
stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G …

Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer

Y Wu, L Yang, J Zhao, C Li, J Nie, F Liu, C Zhuo… - Molecular cancer, 2015 - Springer
Background High expression of the long non-coding RNA nuclear-enriched abundant
transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; …

Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy

M Petrina, J Martin, S Basta - Cytokine & growth factor reviews, 2021 - Elsevier
GM-CSF acts as a pro-inflammatory cytokine and a key growth factor produced by several
immune cells such as macrophages and activated T cells. In this review, we discuss recent …

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential

JA Hamilton - Expert review of clinical immunology, 2015 - Taylor & Francis
Granulocyte-macrophage colony-stimulating factor (GM-CSF) can be viewed as a pro-
inflammatory cytokine rather than as a key regulator of steady state and systemic …