Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are related tyrosine
kinases that have important cellular functions, primarily through regulation of the …

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular
cargos. Numerous kinesins and myosins have evolved to cope with the various transport …

More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define
14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3 …

Cytoplasmic dynein is responsible for many aspects of cellular and subcellular movement.
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental …

Mutations of DISC1 (disrupted-in-schizophrenia 1) have been associated with major
psychiatric disorders. Despite the hundreds of DISC1-binding proteins reported, almost …

Centrosomes are closely associated with the nuclear envelope (NE) throughout the cell
cycle and this association is maintained in prophase when they separate to establish the …

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to
complex regulation involving allosteric mechanisms within the dynein complex, as well as …

Most protein complexes are inaccessible to high resolution structural analysis. We report the
results of a combined approach of cross-linking, mass spectrometry, and bioinformatics to …

Early in infection, adenovirus travels to the nucleus as a naked capsid using the microtubule
motor cytoplasmic dynein. How the dynein complex is recruited to viral cargo remains …

The organization and function of eukaryotic cells rely on the action of many different
molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of …