Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Mechanical properties of cells and extracellular matrix (ECM) play important roles in many
biological processes including stem cell differentiation, tumor formation, and wound healing …

Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

Biomaterials able to promote neuronal development and neurite outgrowth are highly
desired in neural tissue engineering for the repair of damaged or disrupted neural tissue …

Detailed knowledge of mechanical parameters such as cell elasticity, stiffness of the growth
substrate, or traction stresses generated during axonal extensions is essential for …

A growing body of work describes how physical forces in and around cells affect their
growth, proliferation, migration, function and differentiation into specialized types. How cells …

Recent results indicate that, in addition to chemical cues, mechanical stimuli may also
impact neuronal growth. For instance, unlike most other cell types, neurons prefer soft …

The identity and behavior of a cell is shaped by the molecular and mechanical composition
of its surroundings. Molecular cues have firmly established roles in guiding both neuronal …

Mechanical force plays a fundamental role in neuronal development, physiology, and
regeneration. In particular, research has shown that force is involved in growth cone …