Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk

A Erazo‐Oliveras, M Muñoz‐Vega… - The FEBS …, 2024 - Wiley Online Library
Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …

[HTML][HTML] Diversity of Intercellular Communication Modes: A Cancer Biology Perspective

T Ebrahim, AS Ebrahim, M Kandouz - Cells, 2024 - mdpi.com
From the moment a cell is on the path to malignant transformation, its interaction with other
cells from the microenvironment becomes altered. The flow of molecular information is at the …

NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes

J Fan, J Shi, Y Zhang, J Liu, C An, H Zhu, P Wu… - The EMBO …, 2022 - embopress.org
Stimulatory immune receptor NKG2D binds diverse ligands to elicit differential anti‐tumor
and anti‐virus immune responses. Two conflicting degeneracy recognition models based on …

Membranes on the move: The functional role of the extracellular vesicle membrane for contact‐dependent cellular signalling

K Jahnke, O Staufer - Journal of extracellular vesicles, 2024 - Wiley Online Library
Abstract Extracellular vesicles (EVs), lipid‐enclosed structures released by virtually all life
forms, have gained significant attention due to their role in intercellular and interorganismal …

Understanding immune signaling using advanced imaging techniques

M Brameshuber, E Klotzsch, A Ponjavic… - Biochemical Society …, 2022 - portlandpress.com
Advanced imaging is key for visualizing the spatiotemporal regulation of immune signaling
which is a complex process involving multiple players tightly regulated in space and time …

[HTML][HTML] Cryo-EM elucidates the uroplakin complex structure within liquid-crystalline lipids in the porcine urothelial membrane

H Yanagisawa, Y Kita, T Oda, M Kikkawa - Communications Biology, 2023 - nature.com
The urothelium, a distinct epithelial tissue lining the urinary tract, serves as an essential
component in preserving urinary tract integrity and thwarting infections. The asymmetric unit …

[HTML][HTML] Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in …

N Barvitenko, M Ashrafuzzaman, A Lawen… - Membranes, 2022 - mdpi.com
Chronic low-grade vascular inflammation and endothelial dysfunction significantly contribute
to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory …

Biophysical Interaction Landscape of Mycobacterial Mycolic Acids and Phenolic Glycolipids with Host Macrophage Membranes

AT Srivatsav, S Kapoor - ACS Applied Bio Materials, 2023 - ACS Publications
Lipidic adjuvant formulations consisting of immunomodulatory mycobacterial cell wall lipids
interact with host cells following administration. The impact of this cross-talk on the host …

[HTML][HTML] Unveiling Liquid-Crystalline Lipids in the Urothelial Membrane through Cryo-EM

H Yanagisawa, Y Kita, T Oda, M Kikkawa - bioRxiv, 2023 - ncbi.nlm.nih.gov
The urothelium, a distinct epithelial tissue lining the urinary tract, serves as an essential
component in preserving urinary tract integrity and thwarting infections. The asymmetric unit …

[HTML][HTML] Insights into membrane interactions and their therapeutic potential

C Upton, J Healey, AJ Rothnie, AD Goddard - Archives of Biochemistry and …, 2024 - Elsevier
Recent research into membrane interactions has uncovered a diverse range of therapeutic
opportunities through the bioengineering of human and non-human macromolecules …