Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Complex multicellular organisms require rapid and accurate transmission of information
among cells and tissues and tight coordination of distant functions. Electrical signals and …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Slo1 is a Ca2+-and voltage-activated K+ channel that underlies skeletal and smooth muscle
contraction, audition, hormone secretion and neurotransmitter release. In mammals, Slo1 is …

Malfunctions of potassium channels are increasingly implicated as causes of neurological
disorders. However, the functional roles of the large-conductance voltage-and Ca2+ …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

The voltage-and Ca 2+-activated K+(BK) channels are involved in the regulation of
neurotransmitter release and neuronal excitability. Structurally, BK channels are …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Potassium (K+) channels are expressed in almost every cells and are ubiquitous in neuronal
and glial cell membranes. These channels have been implicated in different disorders, in …