Oxidative stress can be induced by various stimuli and altered in certain conditions,
including exercise and pain. Although many studies have investigated oxidative stress in …

Stress has been consistently linked to negative impacts on physical and mental health. More
specifically, patients with chronic pain experience stress intolerance, which is an …

Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC)
synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying …

Background The treatment of neuropathic pain remains a major unmet need that the
development of personalized and refined treatment strategies may contribute to address …

The concept of fibromyalgia has progressed to achieve a certain consensus regarding the
definition of the condition. We summarize what is known in 2020, be it in terms of diagnosis …

Despite the intense research on developing new therapies for neuropathic pain states,
available treatments have limited efficacy and unfavorable safety profiles. Epigenetic …

Objective: Determine if chronic low back pain (LBP) is associated with DNA methylation
signatures in human T cells that will reveal novel mechanisms and potential therapeutic …

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

Chronic pain is a major public health problem and an economic burden worldwide.
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …

A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been
shown in the literature. Given the need for specific biomarkers to improve OP and FM …