The spleen, an important tissue for the immune system, acts as a filter for blood within the
immune system. Accumulating evidence suggests that the spleen affects a number of brain …

Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and
neuropathic pain) are prevalent in cancer patients and survivors. These mental and …

Purpose: Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4)
correlate with the extent of tumor immune infiltrate, but the mechanisms underlying the …

Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

Aspergillus fumigatus, a ubiquitous mold, is a common cause of invasive aspergillosis (IA) in
immunocompromised patients. Host defense against IA relies on lung-infiltrating neutrophils …

While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Monocytes are recruited from the bone marrow to sites of infection where they release
cytokines and chemokines, function in antimicrobial immunity, and differentiate into …

Background The overall response rate to checkpoint blockade remains unsatisfactory,
partially due to the immune-suppressive tumor microenvironment. A retinoic acid-related …

The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs
in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …

Complications from malaria parasite infections still cost the lives of close to half a million
people every year. The most severe is cerebral malaria (CM). Employing murine models of …