Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Adverse intra-and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

Several lines of evidence from neuropathological studies, human genetics, in vitro
aggregation studies and cellular and animal models support the hypothesis that aSyn plays …

Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …

Fibrillar aggregates of the α-synuclein (αS) protein are the hallmark of Parkinson's Disease
and related neurodegenerative disorders. Characterization of the effects of mutations and …

The role of extracellular α-synuclein (α-syn) in the initiation and the spreading of
neurodegeneration in Parkinson's disease (PD) has been studied extensively over the past …

Background α-Synuclein is a small soluble protein, whose physiological function in the
healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as …