Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
Stiff matrix induces exosome secretion to promote tumour growth
Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …
mechanisms by which ECM regulates its contacting cells have been extensively studied …
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
A Lin, CJ Giuliano, A Palladino, KM John… - Science translational …, 2019 - science.org
Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …
never advance to receive US Food and Drug Administration approval. While lack of efficacy …
TGF-β signaling and resistance to cancer therapy
M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
Targeting TBK1 to overcome resistance to cancer immunotherapy
Y Sun, O Revach, S Anderson, EA Kessler, CH Wolfe… - Nature, 2023 - nature.com
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …
The JNK signaling pathway in inflammatory skin disorders and cancer
MB Hammouda, AE Ford, Y Liu, JY Zhang - Cells, 2020 - mdpi.com
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
[HTML][HTML] KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/MAPK pathway in an m6A-dependent manner
X Lin, R Ye, Z Li, B Zhang, Y Huang, J Du… - Drug Resistance …, 2023 - Elsevier
Non-small cell lung cancer is the leading cause of cancer related mortality worldwide, and
lung adenocarcinoma (LUAD) is one of the most common subtypes. The role of N6 …
lung adenocarcinoma (LUAD) is one of the most common subtypes. The role of N6 …
P21 activated kinase signaling in cancer
CK Rane, A Minden - Seminars in cancer biology, 2019 - Elsevier
Abstract The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …