Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …

Disulfiram (DSF) has been used as an alcoholism drug for 70 years. Recently, it has
attracted increasing attention owing to the distinguished anticancer activity, which can be …

The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due
to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector …

Cancer is a major health issue worldwide and the global burden of cancer is expected to
reduce the costs of treatment as well as prolong the survival time. One of the promising …

Human ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1,
ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that …

In cancer treatment, traditional radiotherapy (RT) is routinely conducted in local tumors and
limited by radioresistance, while recently emerged immunotherapy is confronted with low …

Chemotherapy can induce a robust T cell antitumor immune response by triggering
immunogenic cell death (ICD), a process in which tumor cells convert from nonimmunogenic …

Radiotherapy (RT) is a key treatment for prostate cancer. However, RT resistance can
contribute to treatment failure. Prostate cancer stem cells (PCSCs) are radioresistant. We …

As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …