Sustained release systems for delivery of therapeutic peptide/protein

T Nie, W Wang, X Liu, Y Wang, K Li, X Song… - …, 2021 - ACS Publications
Peptide/protein therapeutics have been significantly applied in the clinical treatment of
various diseases such as cancer, diabetes, etc. owing to their high biocompatibility …

[HTML][HTML] New horizons in hydrogels for methotrexate delivery

A Dehshahri, A Kumar, VS Madamsetty, I Uzieliene… - Gels, 2020 - mdpi.com
Since its first clinical application, methotrexate (MTX) has been widely used for the treatment
of human diseases. Despite great advantages, some properties such as poor absorption …

The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model

A Rahdar, MR Hajinezhad, S Nasri, H Beyzaei… - Journal of Molecular …, 2020 - Elsevier
Methotrexate (MTX) has been often formulated as nano and micro-emulsions, nominally to
address its poor solubility and off-target effects. Nanoformulated MTX is universally reported …

[HTML][HTML] Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration

VA Guilherme, LNM Ribeiro, ACS Alcântara… - Scientific reports, 2019 - nature.com
Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect
many people around the world and are commonly treated with non-steroidal anti …

[HTML][HTML] Development and evaluation of novel leflunomide SPION bioemulsomes for the intra-articular treatment of arthritis

H Abbas, HA Gad, NS El Sayed, LA Rashed… - Pharmaceutics, 2022 - mdpi.com
Systemic treatments for rheumatoid arthritis are associated with many side effects. This study
aimed to minimize the side effects associated with the systemic administration of leflunomide …

[HTML][HTML] Formulation, characterization, and evaluation of eudragit-coated saxagliptin nanoparticles using 3 factorial design modules

Y Alhamhoom, G Ravi, RAM Osmani, U Hani… - Molecules, 2022 - mdpi.com
Background and Introduction: Saxagliptin is a hypoglycemic drug that acts as a dipeptidyl
peptidase-4 (DPP-4) inhibitor and is preferably used in the treatment of Type 2 Diabetes …

Elegant pH-responsive nanovehicle for drug delivery based on triazine dendrimer modified magnetic nanoparticles

A Landarani-Isfahani, M Moghadam, S Mohammadi… - Langmuir, 2017 - ACS Publications
Owing to properties of magnetic nanoparticles and elegant three-dimensional
macromolecule architectural features, dendrimeric structures have been investigated as …

A 3 2 full factorial design for development and characterization of a nanosponge-based intravaginal in situ gelling system for vulvovaginal candidiasis

RAM Osmani, PK Kulkarni, S Shanmuganathan… - RSC …, 2016 - pubs.rsc.org
Clotrimazole (CTZ) is a Biopharmaceutics Classification System (BCS) Class II drug having
a limited therapeutic potential because of its poor aqueous solubility and relatively short half …

[PDF][PDF] Nano structured lipid carrier based drug delivery system

G Karunakar, NP Patel, SS Kamal - J Chem Pharm Res, 2016 - researchgate.net
The primary objective of writing this article is to put the emphasis on the importance of nano
structured based drug delivery systems. Although drugs as such can be delivered in the …

[HTML][HTML] A bird's eye view of various cell-based biomimetic nanomedicines for the treatment of arthritis

N Vasdev, B Pawar, T Gupta, M Mhatre, RK Tekade - Pharmaceutics, 2023 - mdpi.com
Arthritis is the inflammation and tenderness of the joints because of some metabolic,
infectious, or constitutional reasons. Existing arthritis treatments help in controlling the …