Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …

The consensus cis-regulatory AP-1 (activator protein-1)-like AREs (antioxidant-response
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …

Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-
restricted transcription factors. The transcription factors that determine the decision between …

Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …

Hematopoietic stem (HSC) and progenitor (HPC) cell fate is governed by intrinsic and
extrinsic parameters. We examined the impact of hematopoietic niche elements on HSC and …

BACKGROUND: IL-22 controls tissue homeostasis by both proinflammatory and anti-
inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly …

A growing body of evidence suggests that megakaryocytes (MK) or their growth factors play
a role in skeletal homeostasis. MK have been shown to express and/or secrete several bone …

Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche
is critical for stem cell function and maintenance of the stem cell pool. We characterized …

Rationale: The hematopoietic system and skeletal system have a close relationship, and
megakaryocytes (MKs) may be involved in maintaining bone homeostasis. However, the …

Recent data suggest that megakaryocytes (MKs) play a role in skeletal homeostasis. In vitro
and in vivo data show that MKs stimulate osteoblast (OB) proliferation and inhibit osteoclast …