[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation
M Murakami, R Takamiya, Y Miki, N Sugimoto… - Biochemical …, 2022 - Elsevier
Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
PLA2G4E, a candidate gene for resilience in Alzheimer s disease and a new target for dementia treatment
M Pérez-González, M Mendioroz, S Badesso… - Progress in …, 2020 - Elsevier
Clinical studies revealed that some aged-individuals accumulate a significant number of
histopathological Alzheimer´ s disease (AD) lesions in their brain, yet without developing …
histopathological Alzheimer´ s disease (AD) lesions in their brain, yet without developing …
The rise and fall of anandamide: processes that control synthesis, degradation, and storage
RG Biringer - Molecular and cellular biochemistry, 2021 - Springer
Anandamide is an endocannabinoid derived from arachidonic acid-containing membrane
lipids and has numerous biological functions. Its effects are primarily mediated by the …
lipids and has numerous biological functions. Its effects are primarily mediated by the …
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme
S Butini, S Gemma, G Campiani - 2020 - books.rsc.org
The fatty acid amide hydrolase (FAAH, EC 3.5. 1.99) is an integral intracellular membrane-
bound enzyme that was properly characterized in the mid-1980s, 1 although an N …
bound enzyme that was properly characterized in the mid-1980s, 1 although an N …
Inhibition of NAPE-PLD Activity by Natural Compounds and Synthetic Drugs, and Its Biological Relevance
K Tsuboi, T Uyama, N Ueda - 2020 - books.rsc.org
N-Acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) is a key
enzyme involved in the biosynthesis of the endocannabinoid anandamide. In this chapter …
enzyme involved in the biosynthesis of the endocannabinoid anandamide. In this chapter …
[PDF][PDF] Inhibitor discovery of phospholipases and N-acyltransferases
J Zhou - J. Biomed. Sci, 2015 - scholarlypublications …
In Chapter 1, the endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) is
described as an endogenous ligand capable of activating the cannabinoid receptors. A part …
described as an endogenous ligand capable of activating the cannabinoid receptors. A part …