Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come

P Yingchoncharoen, DS Kalinowski… - Pharmacological …, 2016 - ASPET
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

[HTML][HTML] Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections

Y Liu, R Qin, SAJ Zaat, E Breukink… - Journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Antibacterial photodynamic therapy (APDT) has drawn increasing attention from the
scientific society for its potential to effectively kill multidrug-resistant pathogenic bacteria and …

Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies

M Broekgaarden, R Weijer, TM van Gulik… - Cancer and Metastasis …, 2015 - Springer
Photodynamic therapy (PDT) has emerged as a promising alternative to conventional
cancer therapies such as surgery, chemotherapy, and radiotherapy. PDT comprises the …

Zinc (II) phthalocyanines as photosensitizers for antitumor photodynamic therapy

LP Roguin, N Chiarante, MCG Vior, J Marino - The international journal of …, 2019 - Elsevier
Photodynamic therapy (PDT) is a highly specific and clinically approved method for cancer
treatment in which a nontoxic drug known as photosensitizer (PS) is administered to a …

[HTML][HTML] Immune targets in the tumor microenvironment treated by radiotherapy

OM Ozpiskin, L Zhang, JJ Li - Theranostics, 2019 - ncbi.nlm.nih.gov
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after
diagnosis, has the advantage of local tumor control with relatively less systematic side …

Photonanomedicine: a convergence of photodynamic therapy and nanotechnology

G Obaid, M Broekgaarden, AL Bulin, HC Huang… - Nanoscale, 2016 - pubs.rsc.org
As clinical nanomedicine has emerged over the past two decades, phototherapeutic
advancements using nanotechnology have also evolved and impacted disease …

[HTML][HTML] Dihydroartemisinin increases the sensitivity of photodynamic therapy via NF-κB/HIF-1α/VEGF pathway in esophageal cancer cell in vitro and in vivo

Y Li, H Sui, C Jiang, S Li, Y Han, P Huang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Although photodynamic therapy (PDT) can relieve esophageal
obstruction and prolong survival time of patients with esophageal cancer, it can induce …

[HTML][HTML] Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

R Weijer, M Broekgaarden, M Krekorian, LK Alles… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background: Photodynamic therapy (PDT) induces tumor cell death by oxidative stress and
hypoxia but also survival signaling through activation of hypoxia-inducible factor 1 (HIF-1) …

Photodynamic therapy with liposomal zinc phthalocyanine and tirapazamine increases tumor cell death via DNA damage

M Broekgaarden, R Weijer, AC van Wijk… - Journal of …, 2017 - ingentaconnect.com
The efficacy of photodynamic therapy (PDT) in some solid tumors is limited by the poor
biodistributive properties of conventional photosensitizers and a natural predisposition of …

[HTML][HTML] Metallated phthalocyanines and their hydrophilic derivatives for multi-targeted oncological photodynamic therapy

LM Dias, MJ de Keijzer, D Ernst, F Sharifi… - … of Photochemistry and …, 2022 - Elsevier
Background and aim A photosensitizer (PS) delivery and comprehensive tumor targeting
platform was developed that is centered on the photosensitization of key pharmacological …