Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …

Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall
glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been …

The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

Despite high expression levels at the plasma membrane or in intracellular vesicles,
tetraspanins remain among the most mysterious transmembrane molecules 20 years after …

We present evidence for a specific role of p53 in the mitochondria-associated cellular
dysfunction and behavioral abnormalities of Huntington's disease (HD). Mutant huntingtin …

Visual transduction in the Drosophila compound eye functions through a pathway that
couples rhodopsin to phospholipase C (PLC) and the opening of transient receptor potential …

Small transmembrane proteins of the tetraspanin superfamily are believed to function as the
main structural blocks of specialized membrane microdomains (referred to as tetraspanin …

Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal
dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others …

Tetraspanins are evolutionarily conserved membrane proteins that tend to associate
laterally with one another and to cluster dynamically with numerous partner proteins in …