Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

The recent development of experimental methods for measuring chromatin state at single-
cell resolution has created a need for computational tools capable of analyzing these …

Although chimeric antigen receptor (CAR) T cells have altered the treatment landscape for B
cell malignancies, the risk of on-target, off-tumour toxicity has hampered their development …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism,
contributing to cellular heterogeneity and disease. Diverse mutations are associated with …

Single-cell measurements of cellular characteristics have been instrumental in
understanding the heterogeneous pathways that drive differentiation, cellular responses to …

Single-cell transcriptomic approaches have revolutionised the study of complex biological
systems, with the routine measurement of gene expression in thousands of cells enabling …