The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …

The use of particulate carriers holds great promise for the development of effective and
affordable recombinant vaccines. Rational development requires a detailed understanding …

Influenza A virus (IAV) enters host cells upon binding of its hemagglutinin glycoprotein to
sialylated host cell receptors. Whereas dynamin-dependent, clathrin-mediated endocytosis …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the
United States. The precise role of bacterial infection in the course and pathogenesis of …

Nontypeable Haemophilus influenzae colonizes the respiratory tract of adults with chronic
obstructive pulmonary disease (COPD) and causes intermittent exacerbations. Isolates of H …

Adherence and invasion are thought to be key events in the pathogenesis of non‐typeable
Haemophilus influenzae (NTHi). The role of NTHi lipooligosaccharide (LOS) in adherence …

Biofilms of pathogenic bacteria are present on the middle ear mucosa of children with
chronic otitis media (COM) and may contribute to the persistence of pathogens and the …

Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis
media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H …

The frequency of colonization and intracellular localization of nontypeable Haemophilus
influenzae (NTHi) in the lower respiratory tract was determined in healthy adults and in …

Known therapies for influenza A virus infection are complicated by the frequent emergence
of resistance. A therapeutic strategy that may escape viral resistance is targeting host …