Thyroid hormones are crucial for organismal development and homeostasis. In humans,
untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism …

Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

The epithelial and mesenchymal cells involved in early embryonic facial development are
guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

A locus on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of
papillary thyroid carcinoma (PTC). The locus also comprises the forkhead box E1 (FOXE1) …

Orofacial clefts, including cleft palates (CP), are one of the most common birth defects. CP
have a multiplicity of effects on the individual and society in terms of economic costs, loss of …

Thyroid differentiation of progenitor cells occurs during embryonic development and in the
adult thyroid gland, and the molecular bases of these complex and finely regulated …

Background FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid
gland development, as well as for the maintenance of the thyroid differentiated state in …