Recent advances of chitosan as a hemostatic material: Hemostatic mechanism, material design and prospective application

S Zhang, X Lei, Y Lv, L Wang, LN Wang - Carbohydrate Polymers, 2024 - Elsevier
Uncontrolled hemorrhage arising from surgery or trauma may cause morbidity and even
mortality. Therefore, facilitating control of severe bleeding is imperative for health care …

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

X Jia, X Fan, C Chen, Q Lu, H Zhou, Y Zhao… - …, 2024 - ACS Publications
As a biodegradable and biocompatible protein derived from collagen, gelatin has been
extensively exploited as a fundamental component of biological scaffolds and drug delivery …

Gelatin sponges with a uniform interoperable pore structure and biodegradability for liver injury hemostasis and tissue regeneration

Y Du, Y Bai, S Lang, D Xing, L Ma, K Li, J Peng… - …, 2023 - ACS Publications
Developing a hemostatic sponge that can effectively control bleeding from visceral injuries
while guiding in situ tissue regeneration in incompressible wounds remains a challenge …

Engineering injectable hyaluronic acid-based adhesive hydrogels with anchored PRP to pattern the micro-environment to accelerate diabetic wound healing

W Duan, X Jin, Y Zhao, S Martin-Saldaña, S Li… - Carbohydrate …, 2024 - Elsevier
Diabetic wounds remain a global challenge due to disordered wound healing led by
inflammation, infection, oxidative stress, and delayed proliferation. Therefore, an ideal …

[HTML][HTML] A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage

X Du, T Zhang, Y Liu, T Li, J Yang, X Li, L Wang - Materials Today Bio, 2024 - Elsevier
Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for
the effective management of uncontrolled coagulopathic hemorrhage remains a challenge …

A shape memory cationized chitosan sponge loaded with thrombin for high-effective hemostasis and antibacterial activity

M Ma, Y Guo, R Ji, L Wang, Y Zhang, X Du… - International Journal of …, 2024 - Elsevier
This study presents a thrombin-loaded cationized chitosan (TCCS) sponge with highly
effective hemostatic and antibacterial activity. The TCCS sponge, prepared using a multistep …

A 3D‐Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage

X Zhang, X Wang, P Yuan, C Ma, Y Wang, Z Zhang… - Small, 2024 - Wiley Online Library
Developing a self‐expanding hemostatic sponge with high blood absorption and rapid
shape recovery for noncompressible hemorrhage remains a challenge. In this study, a 3D …

Highly Deformable and Robust Ionic Structure for Multi‐Tissue Adaptive Hemostatic Sponges

C Song, S Wang, Z Zhang, K Kong… - Advanced Functional …, 2024 - Wiley Online Library
Accidental trauma is always accompanied by tissue defects with noncompressible
hemorrhages. Deformable and tough biomaterials are desirable for self‐compressible …

A self-elastic chitosan sponge reinforced with lauric acid-modified quaternized chitosan and attapulgite to treat noncompressible hemorrhage and facilitate wound …

X Du, X Zhao, Y Liu, Y Chen, R Li, T Zhang… - Carbohydrate Polymers, 2024 - Elsevier
The development of self-elastic sponges with enhanced hemostatic and antibacterial
properties to treat noncompressible hemorrhage and facilitate wound healing remains …

[HTML][HTML] Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions

CY Zou, C Han, F Xing, YL Jiang, M Xiong, J Li-Ling… - Bioactive Materials, 2025 - Elsevier
Uncontrolled hemorrhage remains the leading cause of death in clinical and emergency
care, posing a major threat to human life. To achieve effective bleeding control, many …