The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a
major public health concern, as carbapenems are a therapy of last resort against this family …

Objectives Recent reports indicate the emergence of a new carbapenemase-producing
Klebsiella pneumoniae clone, ST307. We sought to better understand the global …

The global spread of Klebsiella pneumoniae producing Klebsiella pneumoniae
carbapenemase (KPC) has been mainly associated with the dissemination of high-risk …

Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and
mortality rates. The emergence and spread of strains resistant to multiple antimicrobial …

Carbapenem-sparing strategies should be used, when feasible, for ESBL infections. The
majority of available nonrandomized studies highlight that combination for CRE seem to …

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially
with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of …