Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …

T lymphocytes are the central regulatory cells of the immune system. Much of their function is
mediated by a set of small proteins whose expression, secretion, or both is induced as a …

Elimination of CD25+ T cells, which constitute 5-10% of peripheral CD4+ T cells in normal
naive mice, leads to spontaneous development of various autoimmune diseases. These …

Background Type 1 diabetes mellitus is a chronic autoimmune disease caused by the
pathogenic action of T lymphocytes on insulin-producing beta cells. Previous clinical studies …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

This study shows that the normal thymus produces immunoregulatory CD25+ 4+ 8−
thymocytes capable of controlling self-reactive T cells. Transfer of thymocyte suspensions …

Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …

DIABETES mellitus is simply defined on the basis of hyperglycemia. It is, however, a highly
heterogeneous disease. A major advance was made in the late 1960s when insulin …

CD4'T cells play a key role in regulating immune system function. When these regulatory
processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …