Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …

This chapter reviews the physiological and pathological roles of TRPV5 and TRPV6 and
discusses a variety of techniques that have led to a deeper understanding of these …

TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel
essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close …

Primary hyperparathyroidism (PHPT) is the third most common endocrine disease. Kidney is
a target of both chronic elevated PTH and calcium in PHPT. The classic PHPT complications …

Transient receptor potential (TRP) channels are a large and diverse family of
transmembrane ion channels that are widely expressed, have important physiological roles …

The majority of calcium filtered by the glomerulus is reabsorbed along the nephron. Most is
reabsorbed from the proximal tubule (> 60%) via a paracellular pathway composed of the …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

Calcium ions (Ca2+) are crucial for a variety of cellular functions. The extracellular and
intracellular Ca2+ concentrations are thus tightly regulated to maintain Ca2+ homeostasis …

Hypercalciuria is the most common metabolic risk factor in people with kidney stone
disease. Its etiology is mostly multifactorial, although monogenetic causes of hypercalciuria …

Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been
classified into six subfamilies. They are unique mediators of sensory signals with multiple …