The hepatocyte is a polarized cell with a distinct basolateral and an apical (bile canalicular)
domain. Transport processes at the two poles of the cell show a high degree of specifi~ ity.' …

Using complementary physical-chemical techniques we defined five different crystallization
pathways as functions of time (30 days) and increasing lecithin (egg yolk) content in …

Precipitation of cholesterol in gallbladder bile is believed to produce platelike cholesterol
monohydrate crystals directly. We report complementary time-lapse microscopic studies of …

Cholesterol, a highly insoluble molecule, is transported in bile by specialized lipid
aggregates. On the basis of extensive correlations between laboratory-prepared model biles …

The liver is a vital organ involved in numerous metabolic processes such as cholesterol and
bile acid metabolism, biliary lipid secretion, and bile formation. Cholesterol balance across …

We employed quasielastic and static light scattering to measure apparent values of the
mean hydrodynamic radii (R h) app, molecular weights (M app), and radii of gyration (R g) …

Phosphatidylcholine transfer protein (PC-TP) is a 214-amino acid cytosolic protein that
promotes intermembrane transfer of phosphatidylcholines, but no other phospholipid class …

Revised Manuscript Received June 2, 1994® abstract: Using model systems, we explored a
potential function of hepatic phosphatidylcholine transfer protein to extract biliary-type …

We determined the distribution of lecithin molecular species between vesicles and mixed
micelles in cholesterol super-saturated model biles (molar taurocholate-lecithin-cholesterol …

Because gallstones form so frequently in human bile, pathophysiologically relevant
supersaturated model biles are commonly employed to study cholesterol crystal formation …