Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders
BR Ferguson, WJ Gao - Frontiers in neural circuits, 2018 - frontiersin.org
Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …
complex behaviors, including working memory, cognitive flexibility, attention, social …
What constitutes the prefrontal cortex?
M Carlén - Science, 2017 - science.org
During evolution, the prefrontal region grew in size relative to the rest of the cortex. It
reached its largest extent in the human brain, where it constitutes 30% of the total cortical …
reached its largest extent in the human brain, where it constitutes 30% of the total cortical …
A neuronal circuit for activating descending modulation of neuropathic pain
J Huang, VM Gadotti, L Chen, IA Souza, S Huang… - Nature …, 2019 - nature.com
Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …
components, the underlying brain circuitry of which remains poorly understood. In the …
Hippocampal–prefrontal input supports spatial encoding in working memory
Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of
seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and …
seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and …
The role of medial prefrontal cortex in memory and decision making
DR Euston, AJ Gruber, BL McNaughton - Neuron, 2012 - cell.com
Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making.
Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet …
Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet …
The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
Medial prefrontal cortex in neurological diseases
P Xu, A Chen, Y Li, X Xing, H Lu - Physiological genomics, 2019 - journals.physiology.org
The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output …
from numerous cortical and subcortical areas and converges updated information to output …
Mouse prefrontal cortex represents learned rules for categorization
S Reinert, M Hübener, T Bonhoeffer, PM Goltstein - Nature, 2021 - nature.com
The ability to categorize sensory stimuli is crucial for an animal's survival in a complex
environment. Memorizing categories instead of individual exemplars enables greater …
environment. Memorizing categories instead of individual exemplars enables greater …
Circuit-based corticostriatal homologies between rat and primate
SR Heilbronner, J Rodriguez-Romaguera, GJ Quirk… - Biological …, 2016 - Elsevier
Background Understanding the neural mechanisms of psychiatric disorders requires the use
of rodent models; however, frontal-striatal homologies between rodents and primates are …
of rodent models; however, frontal-striatal homologies between rodents and primates are …