Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

During evolution, the prefrontal region grew in size relative to the rest of the cortex. It
reached its largest extent in the human brain, where it constitutes 30% of the total cortical …

Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …

Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of
seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and …

Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making.
Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet …

Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output …

The ability to categorize sensory stimuli is crucial for an animal's survival in a complex
environment. Memorizing categories instead of individual exemplars enables greater …

Background Understanding the neural mechanisms of psychiatric disorders requires the use
of rodent models; however, frontal-striatal homologies between rodents and primates are …