This review presents an overview of the dynamically developing field of mass spectrometry‐
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …

Eicosanoids have been implicated in a vast number of devastating inflammatory conditions,
including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …

Cyclooxygenase, lipoxygenase, and epoxygenase derived oxylipins, especially
eicosanoids, play important roles in many physiological processes. Assessment of oxidized …

Medical diagnosis and treatment efficacy will improve significantly when a more
personalized system for health assessment is implemented. This system will require …

Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the
initiation and resolution of inflammation. These compounds, also referred to as lipid …

Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as
epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second …

Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely
accepted but the mechanism (s) by which these fatty acids act remains unclear. Herein, we …

We previously reported that laminar flow activates peroxisome proliferator-activated receptor
γ (PPARγ) in vascular endothelial cells in a ligand-dependent manner that involves …

Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic
acids (EETs); however, the functional role of this P450 and its eicosanoid products in the …