[HTML][HTML] piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure

N Zhong, X Nong, J Diao, G Yang - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Purpose: Previous studies found that piRNAs could participate in disease progression by
regulating DNA methylation, but there are few reports on their roles in heart failure (HF) …

Engines of innovation: biological origins of genome evolution

JA Shapiro - Biological Journal of the Linnean Society, 2023 - academic.oup.com
Genome change does not occur accidentally. The conventional Modern Synthesis view of
gradual evolution guided solely by natural selection fails to incorporate many important …

piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice

A Jiao, H Liu, H Wang, J Yu, L Gong, H Zhang, L Fu - Cellular Signalling, 2024 - Elsevier
PIWI-interacting RNAs (piRNAs) are involved in the regulation of hypertrophic
cardiomyopathy, heart failure and myocardial methylation. However, their functions and the …

Impact of Heat Stress on Transposable Element Expression and Derived Small RNAs in Drosophila subobscura

A Bodelón, M Fablet… - Genome Biology and …, 2023 - academic.oup.com
Global warming is forcing insect populations to move and adapt, triggering adaptive genetic
responses. Thermal stress is known to alter gene expression, repressing the transcription of …

[PDF][PDF] High Stability of the Epigenome in Drosophila Interspecific Hybrids

A Bodelón, M Fablet, P Veber, C Vieira… - Genome biology and …, 2022 - academic.oup.com
Interspecific hybridization is often seen as a genomic stress that may lead to new gene
expression patterns and deregulation of transposable elements (TEs). The understanding of …

Impact of stress in gene and Transposable Element expression in Drosophila

A Bodelon De Frutos - tdx.cat
Transposable Elements (TEs) are repetitive DNA sequences that can move from one
location to another in the host genome. New TE insertions are usually detrimental for the …