The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …

The blood–brain barrier (BBB) maintains the optimal microenvironment in the central
nervous system (CNS) for proper brain function. The BBB comprises specialized CNS …

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that
interacts directly with astrocytes, neurons and pericytes. It protects the brain from the …