A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

HIV-1 contains a cone-shaped capsid encasing the viral genome. This capsid is thought to
follow fullerene geometry—a curved hexameric lattice of the capsid protein, CA, closed by …

With a significant role in material sciences, physics,(soft matter) chemistry, and biology, the
transmission electron microscope is one of the most widely applied structural analysis tool to …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

Influenza virus remains a global health threat, with millions of infections annually and the
impending threat that a strain of avian influenza may develop into a human pandemic …

Summary HIV-1 reverse transcription (RT) occurs before or during uncoating, but the cellular
compartment where RT and uncoating occurs is unknown. Using imaging and biochemical …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

Human immunodeficiency virus type 1 (HIV-1) infection is highly dependent on its capsid.
The capsid is a large container, made of∼ 1,300 proteins with altogether 4 million atoms …