Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Acute psychological stress has long been known to decrease host fitness to inflammation in
a wide variety of diseases, but how this occurs is incompletely understood. Using mouse …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some
adult humans, residuals of brown adipose tissue are adjacent to the central nervous system …

Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT)
physiology in rodents housed below their thermoneutral zone (ie, 28–32° C). In these …

Multilocular adipocytes are a hallmark of thermogenic adipose tissue,, but the factors that
enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte …