Clinical decision-making and algorithmic inequality
Decision support algorithms based on historical data will make recommendations that are
influenced by past inequality. Detailed historical health data contain patterns that identify …
influenced by past inequality. Detailed historical health data contain patterns that identify …
Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
AP Doumatey, D Shriner, J Zhou, L Lei, G Chen… - Genome Medicine, 2024 - Springer
Abstract Background Type 2 diabetes (T2D) has reached epidemic proportions globally,
including in Africa. However, molecular studies to understand the pathophysiology of T2D …
including in Africa. However, molecular studies to understand the pathophysiology of T2D …
Advancing equity in human genomics through tissue-specific multi-ancestry molecular data
There is a pressing need to generate molecular data from diverse tissues across global
populations. These currently missing data are necessary to resolve genome-wide …
populations. These currently missing data are necessary to resolve genome-wide …
[PDF][PDF] Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All
K Venkatakrishnan, KE Brown… - Clinical …, 2023 - scholarlypublications …
Pharmacology and Therapeutics (CPT) has adopted DEI as core guiding principles in our
field. 1, 2 Building upon CPT's mini-themes on the topic in October 2021 1 and August 2022 …
field. 1, 2 Building upon CPT's mini-themes on the topic in October 2021 1 and August 2022 …
TEMR: Trans-ethnic Mendelian Randomization Method using Large-scale GWAS Summary Datasets
L Hou, S Wu, Z Yuan, H Li, F Xue - medRxiv, 2024 - medrxiv.org
Available large-scale GWAS summary datasets predominantly stem from European
populations, while sample sizes for other ethnicities, notably Central/South Asian, East …
populations, while sample sizes for other ethnicities, notably Central/South Asian, East …
Exploring the Pannexin 1 interactome: In silico cross-analyses with postsynaptic proteins and neuropsychiatric disorder susceptibility genes
The Pannexin 1 (Panx1) channel-forming protein is enriched in the central nervous system,
and has been associated with several critical neurodevelopmental and plasticity functions; …
and has been associated with several critical neurodevelopmental and plasticity functions; …
[图书][B] Functional genomics study of neuropsychiatric disorders through integration of chromatin regulation, transcriptomics, and metabolomics
TA Boltz - 2023 - search.proquest.com
This dissertation examines significant risk loci identified through GWAS for neuropsychiatric
illness to prioritize causal variants and genes for future validation in functional assays. This …
illness to prioritize causal variants and genes for future validation in functional assays. This …
Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic
convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked …
convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked …