Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

Prediction models in health care use predictors to estimate for an individual the probability
that a condition or disease is already present (diagnostic model) or will occur in the future …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …

Background Previous studies have developed models predicting methylation age from DNA
methylation in blood and other tissues (epigenetic clock) and suggested the difference …

DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …

Background The discovery of low-frequency coding variants affecting the risk of coronary
artery disease has facilitated the identification of therapeutic targets. Methods Through DNA …

Case-control studies are one of the major observational study designs for performing clinical
research. The advantages of these study designs over other study designs are that they are …

Background The major challenge for obstetrics is the prediction and prevention of the great
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …

Background First metabolomics studies have indicated that metabolic fingerprints from
accessible tissues might be useful to better understand the etiological links between …